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Methods, Possibilities and Perspectives of Pre-symptomatic Tumor Diagnostics, by K. Conrad, M. Bachmann, W. Lehmann, U. Sack (Eds.)

Category: Medicine/Medical books
Item number: ISBN 3-89967-254-2
Price: 50.00 EUR   (w/o VAT 46.73)
Info:
2005, 348 pages
ISBN 3-89967-254-2

There is no doubt that the early diagnosis of tumors is the most effective way to reduce the mortality caused by neo-plastic diseases. Pre-symptomatic tumor diagnostics may be considered as secondary prevention by effective screening to identify cancer at a localized and curable stage. In this book methods, possibilities and perspectives of pre-symptomatic tumor diagnostics will be discussed. Because of the heterogeneity of tumors in genes and protein expres-sion as well as in the biological behaviour one approach alone is insufficient for a highly specific, sensitive and cost-effective screening. In four chapters the requirements for an effective screening, the value of conventional "screening" methods (tumor markers, anatomical imaging modalities), and the search for novel biomarkers (tumor associated genes, antigens and autoantibodies) in terms of non-imaging screening as well as novel developments in imaging tech-nologies and endoscopical approaches will be described.
Pre-symptomatic tumor diagnostics is a complex field that needs interdisciplinary research. The societies Gesellschaft für Immundiagnostik e.V. (www.gfid.de) and Präsymptomatische Tumordiagnostik e.V. (www.tumornetzwerk.de) co-operate to provide a communication platform - "Innovation Forum Pre-symptomatic Tumor Diagnostics" - that sup-ports complex research projects between clinicians, researchers, and industry to develop and validate new diagnostic technologies and products. This national platform will be turned into an international institution in the future.


Contents:

INTRODUCTION

H.-H. König: Economic aspects of pre-symptomatic tumor diagnostics

P. Oehr: Perspectives of molecular diagnostics – From “omics“ to molecular imaging


Chapter 1: TUMOR AND AUTOIMMUNITY

J.-Y. Zhang, E. K.L. Chan: Tumor specific autoimmune responses - Why and when do they develop?

K. Conrad, D. Roggenbuck, M. Bachmann: Autoantibodies as indicators of tumor development

M. Koslowski, Ö. Türeci, U. Sahin: Identification of tumor-associated autoantibodies by SEREX technology

M. Montenarh: p53 autoantibodies in the diagnosis and prognosis of tumors

K. Großmann, U. Wagner, S. Milius, K. Conrad, U. Canzler, M. Bachmann, W. Lehmann: The microblot – a new tool for multiparameter immunodiagnostics


Chapter 2: BIOMARKER AND PROTEOMIC ANALYSES

R. Lamerz, P. Stieber: Tumor markers – Diagnostic relevance and perspectives

B. Seliger: Identification of diagnostic biomarkers for tumors by proteome analysis

S. Klein-Scory, W. Schmiegel, I. Schwarte-Waldhoff: Immunosecretomics: Identification of tumor associated antigens by serological screening of tumor cell secretomes

J. Lichey: Overview and perspectives for the SELDI technology in early cancer diagnosis

T. Elssner, M. Kostrzewa: CLINPROT – a MALDI-TOF MS based system for biomarker discovery and analysis

A. Wiesner: ProteinChip® technology – Chances and perspectives in tumor diagnostics

S. Holdenrieder: Circulating apoptotic markers in the diagnosis and prognosis of malignant tumors

K. Schnurr, V. Muravsky, G. Seibt, G. Matthes: The analysis of functional characteristics of serum albumin – a novel possibility of early cancer diagnosis


Chapter 3: GENETIC ANALYSES AND DISSEMINATED TUMOR CELLS

B. Jandrig: Identification and analysis of hereditary cancer susceptibility

C. Pilarsky, R. Grützmann: The use of microarray based gene expression profiling for the diagnosis of malignancies

M. Fleischhacker, B. Schmidt: Circulating nucleic acids – do they have a meaning in cancer research?

A. Meye: Disseminated tumor cells in blood and bone marrow in patients with urologic tumors – Methods of detection and relevance

U. Anderer: Human tumor cells in vivo & in vitro: Modulation of differentiation and behaviour - Influence on in vitro cytotoxicity testing?


Chapter 4: IMAGING TECHNOLOGIES AND ENDOSCOPICAL METHODS

M. Hentschel, F. Müller, I. Brink: Potentials and limits of combined anatomical and functional imaging modalities in tumor diagnosis

F. Stanzel: Autofluorescence bronchoscopy in early detection of central premalignant and malignant bronchial changes

M. Hocke, E. Schulze, P. Gottschalk, C. F. Dietrich: The use of contrast enhanced endoscopic ultrasound in discrimi-nation between focal pancreatitis and pancreatic cancer

C. Krafft, W. Steller, R. Salzer: Infrared spectroscopic imaging - an analytical tool for tumor diagnostics

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