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Scientists in Brazil on Tuesday provided a markedly less enthusiastic assessment of the efficacy of a Chinese coronavirus vaccine that they hailed as a major triumph last week.

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The researchers identified a sleep-like state in a tiny, brainless animal called a hydra. - Our brains need sleep to work properly. But it turns out you don't need a brain to sleep. In a new study, researchers identified a sleep-like state in a tiny, freshwater animal called a hydra, which has a simple anatomy and lacks a brain. "We now have strong evidence that animals must have acquired the need to sleep before acquiring a brain," study lead author Taichi Q. Itoh, an assistant professor at Kyushu University in Japan, said in a statement. The study, recently published in the journal Science Advances, has implications for our understanding of the reason the need for zzzs evolved.

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Dozens of coronavirus vaccines entered clinical trials during 2020, and now, a handful have been authorized for emergency use in various countries — meaning the shots can be administered to the public while their developers continue to collect data on their safety and efficacy. Should they meet all the necessary criteria, these vaccines could be fully approved in the future, and in some places, they already have been.

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Vaccines will likely continue to work against these new strains. - Pfizer's coronavirus vaccine is effective against a key mutation found in variants of the virus that are spreading faster than the original strain, according to an early study.

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Further notification

AMERICAN COLLEGE OF PHYSICIANS | Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.

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These reactions are "exceedingly rare," officials said. - Serious allergic reactions after COVID-19 vaccines are likely more common than serious reactions following flu vaccines, but are still very rare, according to a new report.

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The year 2020 was defined by the coronavirus pandemic, arguably the worst pandemic the world has seen in 100 years. COVID-19 has caused more than 75 million cases and 1.6 million deaths worldwide as of mid-December. The illness has affected nearly every aspect of life, from work and school to everyday activities like getting groceries, and even our wardrobes.

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Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes | KECK SCHOOL OF MEDICINE OF USC

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