"Despite the perceived benefits of transfusion, research has indicated that exposure to allogeneic blood is associated with increased risks of morbidity and mortality following cardiac surgery. Adverse postoperative clinical outcomes, such as renal failure, stroke, pulmonary dysfunction, and infections have been reported. While these complications have been linked to as few as one to two units of donor red blood cells, the impact of patient outcome is believed to be dose-dependent," David C. Fitzgerald and Joseph J. Sistino emphasize (in the new textbook "Extracorporeal Circulation").