"In recent years, patients with advanced end-stage heart failure have increased in numbers. The treatment consists of drug therapy, surgical therapy, mechanical support and heart transplantation. Due to the increasing shortage of organ donors, left ventricular assist devices (LVAD) are becoming the focus of clinical interest - not only as a bridge to heart transplantation, but more and more as an alternative to heart transplantation with destination therapy," PD Dr. Christian Heim (University Erlangen) and colleagues report in the new textbook "Extracorporeal Circulation". The experienced authors describe indications, applications and complications in detail. Additionally, future prospects are discussed: