"The innate control of adaptive immune responses appears to be the center of this regulation. For example, conventional lymphocytes expressing Ag receptors with random specificities require instructions indicating the origin of antigenic pathogen-derived peptide they recognize. These instructions come from the innate immune system in form of specialized ´instructing´molecules induced by PRRs (pattern recognition receptors), such as TLRs (toll-like receptors), which can sense dangerous signals deriving from invading pathogens and arising from inflamed tissue infected by pathogens.
Therefore, the basic principle of innate control of adaptive immunity is based on establishing an association between (1) the pathogen-derived antigens recognized by adaptive immune cells, that is the lymphocites, (2) the PAMPs (pathogen-associated molecular patterns) recognized by PRRs on innate immune cells, and (3) tissues in which the response occurs ..."
Walter G. Land: Innate Alloimmunity, Part 1: Innate Immunity and Host Defense
Baskent University Publisher/Pabst Science Publishers.
654 pages. Hardcover ISBN 978-3-89967-737-9 | ebook ISBN 978-3-89967-737-9