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    Organ Transplantation: The High Relevance to Innate Alloimmunity

    Innate immunity provides much more than an initial host defense against microbial infection. Besides providing a broad range of protection against infection, components of innate immunity respond to tissue injury; they promote repair, contribute to the genesis of autoimmunity, respond to vaccines, and watch for cancer. Beyond these clearly immunological conditions, innate immunity is implicated in allergy, atherosclerosis, malignancy, obesity and osteoporosis conditions that plague many patients including transplant recipients.

    Innate Alloimmunity. Part 2: Innate Immunity and Allograft Rejection

    Prof. Dr. Walter G. Land wrote the textbook "Innate Alloimmunity". In it´s part 2. emphasis is put on those innate events and mechanisms that appear to be relevant to acute and chronic allograft rejection events and typical complications occuring in organ transplantation. The relevant  aspects of innate alloimmunity are described in detail, by also discussing the phenomenon of hypoxia sensing as a potential evolutionary background of reactive oxygen species-initiated pathways resulting in allograft rejection.

    Walter Land wanted to encourage those involved in the development of agents, therapeutics and therapeutic regimens to consider the implications of innate immunity in organ transplantation both to promote effectiveness and prevent potentional complications. Thus, the development of agents that modify innate immunity and their application in fields such as therapeutics for infectious diseases, atherosclerosis, malignancies, and transplantation complications might be usefully considered.

     

    Innate Alloimmunity. Part 2: Innate Immunity and Allograft Rejection
    Land, Walter G
    Pabst, 760 pages

     

    Icon Special and general specialist literatureSpecial scientific titles & generally understandable specialist literature
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