Prof. Dr. Walter G. Land wrote the textbook "Innate Alloimmunity". In it´s part 2. emphasis is put on those innate events and mechanisms that appear to be relevant to acute and chronic allograft rejection events and typical complications occuring in organ transplantation. The relevant aspects of innate alloimmunity are described in detail, by also discussing the phenomenon of hypoxia sensing as a potential evolutionary background of reactive oxygen species-initiated pathways resulting in allograft rejection.
Walter Land wanted to encourage those involved in the development of agents, therapeutics and therapeutic regimens to consider the implications of innate immunity in organ transplantation both to promote effectiveness and prevent potentional complications. Thus, the development of agents that modify innate immunity and their application in fields such as therapeutics for infectious diseases, atherosclerosis, malignancies, and transplantation complications might be usefully considered.