Sepsis is a medical emergency
Infections are the trigger for sepsis, no matter how severe they are or where they develop in the body. Even a urinary tract infection or a minor external injury can be enough to trigger sepsis. "Sepsis occurs when the body's own defence reaction goes into overdrive and attacks its own organs," explains Professor Dr. Sascha David from the Clinic for Kidney and Hypertension Diseases at the MHH and the Institute for Intensive Care Medicine at the University Hospital Zurich. Sepsis is always a medical emergency. Those affected usually have to be treated in an intensive care unit. In severe cases, they receive circulatory support medication, have to be artificially ventilated, and their kidney function has to be supported with dialysis. "It is important to diagnose sepsis early and start therapy immediately," says Professor David. Without medical care, the risk of death increases by seven per cent per hour.
Healthy plasma replaces diseased plasma
Therapeutic plasma exchange is not a new procedure. However, it is not yet established in the treatment of septic shock. Professor David's "Translational Intensive Care Medicine" working group, which also includes private lecturer (PD) Dr Klaus Stahl from the Department of Gastroenterology, Hepatology and Endocrinology and Dr Benjamin Seeliger from the Department of Pneumology, has been working on the topic for several years. Plasma is the liquid component of blood. It contains proteins, mineral salts and many other substances. In plasma exchange, the sick plasma is replaced by the plasma of a healthy person. "In this process, we combine two therapeutic measures with a single intervention," explains PD Dr. Stahl. "On the one hand, the harmful substances present in the diseased plasma, for example, molecules that promote inflammation and disturb blood vessels and circulation, are removed. On the other hand, the protective substances consumed by the sepsis, which have an anti-inflammatory effect and stabilise the vessels and promote blood flow, are replaced by the healthy plasma."
The research group only ever uses the procedure in addition to the other already firmly established treatment measures for sepsis. In smaller studies, they have already achieved good results with the additive therapeutic plasma exchange. The condition of those affected often improved rapidly, even in the case of severe septic shock. "After only two hours, we could see a clear stabilisation of the circulation and after six hours, the circulatory support measures could be reduced by half," reports PD Dr. Stahl.
More than 20 study centres
"The new treatment strategy is safe and has the potential to provide potentially significant benefits for patients. In the new study, we want to find out in a scientifically sound way whether it actually also increases the survival rate. There are many indications that it does," explains Professor David. More than 20 centres in Germany, Switzerland and Austria with about 270 patients are participating in the international study. The study is led by the team of the "Translational Intensive Care Medicine" working group around Professor David and PD Dr. Stahl, as well as PD Dr. Christian Bode from the University Hospital in Bonn. The study, which is funded by the DFG with 1.2 million euros over 36 months, will start at the beginning of 2023.
For further information, please contact Professor Dr Sascha David, firstname.lastname@example.org, and Privatdozent Dr Klaus Stahl, email@example.com.
Therapeutic Plasma Exchange and Selective Plasma Separation Methods
Fundamental Technologies, Pathology and Clinical Results
Bambauer, Rolf; Latza, Reinhard; Schiel, Ralf
2013, 580 pages, 4th ed., ISBN 978-3-89967-732-4 | ebook 978-3-89967-945-8