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From Pathogenesis to Therapy of Autoimmune Diseases, by K. Conrad, E. K. L. Chan, M. J. Fritzler, R.L. Humbel, P. von Landenberg, Y. Shoenfeld (Eds.)

Category: Medicine/Medical books
Item number: ISBN 978-3-89967-579-5
Price: 40.00 EUR   (w/o VAT 37.38)
Info:
2009, 568 pages

In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not only „primary“ autoimmune reactions but also other pathogenic mechanisms such as postinfectious and autoinflammatory processes. The heterogeneity within the immunological diseases may reflect the variable expression of autoinflammatory, autoimmune, and up to now unknown factors in disease development and manifestation. Based on histological and immunohistochemical examinations, IgG4-related sclerosing disease has been proposed as a novel clinicopathological entity with autoimmune phenomena but unknown etiology (chapter 1). The clarification of the etiopathological mechanisms is required to optimize prophylaxis, diagnostics and therapy. Especially, the application of novel and designer biological therapies (chapter 8) requires a better understanding of the processes that are involved in the genesis of immunological diseases. In chapter 2, some aspects of the role of epigenetic mechanisms and innate immunity in the pathogenesis of autoimmune diseases are described. Regardless of the underlying pathology, disease-associated autoantibodies are important biomarkers for the vast majority of non-organ and organ specific autoimmune diseases. However, to improve our understanding of these diseases and serological diagnostics it is necessary to search for novel autoantibodies, to further evaluate the real clinical relevance of known autoantibodies and to further develop and standardize the detection methods (chapters 3-5). Pathogenetic aspects as well as aspects of the serological diagnostics, including novel autoantibody specificities, novel methodologies and evaluation studies are presented for rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic vasculitides, systemic sclerosis (chapter 6) and various organ specific diseases (chapter 7). In summary, the present volume highlights novel insights into the immune dysregulation, pathogenesis, serological diagnostics and biological therapies of autoimmune diseases.


Chapter 1: The Spectrum and Pathogenesis of Noninfectious Inflammatory and Sclerosing Diseases

T. Kamisawa, K. Tsuruta, T. Sasaki: IgG4-related sclerosing disease

M. F. McDermott and D. McGonagle: The autoinflammatory-autoimmune continuum


Chapter 2: The Role of Epigenetics and Innate Immunity in the Pathogenesis of Autoimmune Diseases

O. Sánchez-Pernaute, J. Stanczyk, F. I. Romero-Bueno, S. Gay: MicroRNA in the pathogenesis of systemic lupus: current status and future perspectives

P. von Landenberg: Toll like receptors and autoimmunity

E. Csernok: Proteinase 3 and its receptors: linking innate immunity to autoimmunity in ANCA-associated vasculitides

C. Chizzolini and P. L.Meroni: Agonistic autoantibodies targeting innate immunity receptors:The example of TLR4 in systemic sclerosis

C. M. Hedrich, J. H. Bream: Epigenetic regulation of IL-10 expression: Activation dependent changes in DNA methylation patterns of CD4+ T cell subsets 59


Chapter 3: Novel and Esoteric Autoantibodies

M. J. Fritzler: The clinical paradox of esoteric and novel autoantibodies

A. Kowald, G. Bartsch, H. Klocker,M. Schneider, P. Amersdorfer, S. Müllner, A. Lueking: The UNIarray® technology platform for development of novel autoantibody biomarkers in IVD applications

J.Y. F. Chan,H.Yoshida, A.Mizutani,Y.Yamasaki,Y. Li,M. R. Bubb, E. S. Sobel, E. K. L. Chan, W. H. Reeves,M. Satoh: Autoantibodies to RNA helicase A as a new serological marker of early SLE

M. Blüthner, H. Appelhans, I. Moosbrugger, C.Wiemann, D. Lenz, H. P. Seelig: Identification of inosine-1,2-monophosphate-dehydrogenase-2 as a novel autoantigen

M. Blüthner, H. Appelhans, I. Moosbrugger, C.Wiemann, J. Ludwig, H. P. Seelig: Identification of Rho-GTPase-activating protein p26 as a novel autoantigen

A. Swart, M. Mahler,M. J. Fritzler: The cell cycle protein Nop52 is a candidate target autoantigen

K. Op De Beéck, K. Van den Bergh, L. Maes, G. Michiels, P. Verschueren, R.Westhovens, D. Blockmans, X. Bossuyt: Heterogeneous nuclear ribonucleoproteins, novel target antigens of autoantibodies in autoimmune disease?

K. Somers, R. Hupperts, C. Zwanikken, P. Stinissen and V. Somers: Sperm-associated antigen 16 isoform 2: a novel candidate autoantigen in multiple sclerosis

B. Preuß, J. Dengjel, S. Stevanovic, R. Klein: Identification of the β- and γ-subunits of F1-ATPase as target antigens in anti-M2/PDC-E2 negative primary biliary cirrhosis (PBC) 118

B. Preuß, C. Berg, F. Altenberend,M. Gregor, S. Stevanovic, R. Klein: New autoantibodies in primary sclerosing cholangitis: reactivity with distinct immunodominant epitopes of sulfite oxidase

J. Vencovský, H. Mann, I. Putová, Z. Betteridge, H. Gunawardena, N.McHugh: Anti-p155/140 (anti-TIF1γ) autoantibodies in patients with cancer associated myositis detected in a single centre 122


Chapter 4: Biology of Autoantigen/Autoantibody Systems

W.C. Carcamo, B. Yao, M. Satoh,W.H. Reeves, C. Liu, G. Covini, C.A. von Mühlen, E. K. L. Chan: Cytoplasmic rings/rods as autoimmune targets of emerging human autoantibodies associated with HCV virus infection and interferon therapy

L. S. Leoh,M.Mediavilla-Varela, A. Basu, C. A. Casiano: Autoantibodies to LEDGFp75/DFS70: natural autoantibodies or sensors of an augmented state of cellular oxidative stress?

E. Feist: Circulating proteasomes and autoantibodies


Chapter 5: Methodical Aspects and Diagnostic Strategies

X. Bossuyt: Clinical performance characteristics of a laboratory test

P. L. Meroni: Recommendations of the ACR committee on the standardization of autoantibody detection

A. De Nicolo,M. Tampoia et al:.Laboratory policies on the management of autoimmune diseases in a cohort of Italian laboratories

K.-P.Wandinger, C. Probst, L. Komorowski, S. Saschenbrecker, A. Rosemann, T. Mothes, D. Zillikens, J. Dalmau, S. Jarius, W. Schlumberger,W. Stöcker: Novel recombinant antigenic targets for the determination of (auto)antibodies in autoimmune dermatoses, neurological disorders and gastrointestinal diseases

P. Lorenz, Z. Qian, M. Hecker, M. Kreutzer, F. Steinbeck, Y. Li, M.O. Glocker, H.-J. Thiesen: Stratification of autoantibody signatures in human sera by peptide epitope profiling

M. Mahler and M. Fritzler: Peptide resolved diagnostics in systemic autoimmune diseases: Potentials and pitfalls

R. Hiemann, D. Roggenbuck, U. Sack, K. Conrad: Detection and differentiation of non-organ specific autoantibodies by a fully automated HEp-2 cell assay

K. Großmann, U. Schedler, I. Berger, U. Sack, K. Conrad: Technical solutions and advances for microbead-based immunoassays

K. Großmann, A. Böhm, J. Nitschke, R. Hiemann, P. Schierack, C. Schröder, K. Conrad, U. Sack: Comparison of light sources for measurement of single and multiplex bead assays

S. Signorini, L. Lattuada, R. Colombo: BioPlex™2200 multiplex ANAscreen assay: a novel approach for the detection of antinuclear autoantibodies


Chapter 6: Pathogenetic Aspects and Serological Diagnostics of Systemic Autoimmune Diseases

6.1 Rheumatoid Arthritis

J. J. B. C. van Beers,W. J. van Venrooij, G. J. M. Pruijn: Two major classes of rheumatoid arthritis: CCP distinguishes between ACPA-positive and ACPA-negative RA

G. Steiner, M. Hoffmann: Pathogenic and clinical relevance of rheumatoid arthritis associated autoantibodies

K. Somers, P. Geusens, P. Stinissen, V. Somers: Novel autoantibody targets in seronegative rheumatoid arthritis

M. Lora, J. Rotman, H. A.M´enard, D. Kast, C. Daehnrich,W. Stöcker,W. Schlumberger: Comparison of the research-based anti-Sa with the EUROIMMUN commercial anti-Sa ELISA to monitor rheumatoid arthritis activity

A. Lueking, A. Kowald,M. Schneider, H. E. Meyer, J. Beator, S.Müllner: Development of novel antibody biomarkers for diagnostic protein biochips – the rheumatoid arthritis case study

O. Abade, I. Abreu, F. Pimentel, M. Parente, J. Vaz Patto, R. Figueiredo, D. Ligeiro, C. Miguel, A. Teixeira, H. Trindade: Autoantibody production in early undifferentiated arthritis 319

C. Lingenfelter, S.Merrill, C. Nuun, D. Atkinson, X. Guo,W. Kumfert, T. Prestigiacomo: Diagnostic sensitivity and specificity for rheumatoid arthritis by the Bio-Rad Kallestad ANTI-CCP II assay


6.2: Systemic Lupus Erythematosus

L. E. Munoz, C. Schulze, C. Janko, C. Schorn, K. Sarter, M. Herrmann: The mosaic of the etiopathogenesis of SLE – Role of chromatin binding autoantibodies

F. Stephan, R. Manoe, B. Zwart, I. Bulder, L. Aarden, S. Zeerleder: Decreased nucleosome releasing factor activity in patients with systemic lupus erythematosus

B. Schlüter, G. Bonsmann, M. Gaubitz, P.Willeke: Effect of antigen affinity and isotype specificity on the diagnostic efficiency of anti-dsDNA autoantibody tests in systemic lupus erythematosus patients

R. Tripmacher, C. Kuznia, D. Roggenbuck, T. Büttner, B. Radau, K. Conrad, V. Jansen, A. Schilke, A. Köster, S.Tobisch, B. Spott, R. Lange: Current status of anti-dsDNA antibody diagnostics in the hospital Laborverbund

M. Mahler, M. van Liempt, J. Schulte-Pelkum, S. Schneider, T. Alexander, A. Kromminga, M. Fooke, F. Hiepe: Evaluation of a novel dsDNA ELISA for SLE disease activity measurement

Y. Thabet, A. Achour, A. Mankai,W. Sakly, Y. Renaudineau, P. Youinou, I. Ghedira: Anti-α actinin antibodies in systemic lupus erythematosus

M. A. Lee-Kirsch, D. Chowdhury, S. Harvey, M. Gong, L. Senenko, K. Engel, M. Gahr, J. Lieberman, F.W. Perrino, N. Hubner: A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death causes familial chilblain lupus

L. Ostanek, D. Bobrowska-Snarska, M. Ostanek, A. Binczak-Kuleta, A. Ciechanowicz, M. Brzosko: VEGF gene polymorphisms in patients with systemic Lupus erythematosus

J. C. Möller, G. Hahn, F. Pessler: Corticosteroid-induced spinal epidural lipomatosis in the pediatric patients with chronic autoimmune disorders


6.3: Anti-Phospholipid Syndrome and Systemic Vasculitides

S. D’Ippolito, R.Marana, R. Castellani, C. Tersigni, A. Caruso, N. Di Simone: Antiphospholipid antibodies affect the process of angiogenesis: novel mechanism of placental damage

T. Colasanti, P.Margutti, P.Matarrese, F. Delunardo, B. Ascione, D. Vacirca,W. Malorni, E. Ortona: Gender differences in oxidative stress and apoptosis of vascular cells induced by autoantibodies specific to RLIP76

A. Ceribelli, I. Cavazzana,A.Tincani, F. Franceschini, B. A. Pauley, J.Y. F. Chan, E. K. L. Chan, M. Satoh: Anti-Argonaute2 (Ago2/Su) and -Ro antibodies are the common autoantibody specificities in primary anti-phospholipid syndrome (PAPS)

N. Virstyuk, V. Neyko, E. Cherkachuna, O. Virstyuk: The antiphospholipid antibodies in patients with chronic heart failure

O. Virstyuk, R. D. Gerasymchuk, N. Virstyuk, R. Portyuk: The antiphospholipid syndrome in acute ischemic stroke patients with insulin resistance

M.W. Hayman, C. Slade, K. Chamberlain, N. Cook,M. B. Spellerberg, J. L. O’Donnell: Performance evaluation of PR3-ANCA ELISAs

C. Defendenti, M. F. Spina, M. Longo, S. Bollani, A. Cereda, S. Saibeni, A. Reina, G. Guercilena, S. Bruno, M. Saudelli, F. Atzeni, P. Sarzi-Puttini: Autoimmunity in patientswith anti-neutrophil cytoplasmic antibodies:retrospective analysis of an Italian cohort of ANCA positive patients

L. Cebecauer, V. Král, J. Lupac, I. Lochman: ANCA or other neutrophil specific antibodies (NSA)

Y. Ben Haj Hmida, D. Bouzid, S. Boukthir,M. Ben Ayed, H.Masmoudi: Clinical relevance of ANCA in routine care

A. Radice, L. Bianchi, A. Palumbo, R. A. Sinico: A novel PR3-ANCA ELISA with a mixture of human purified and recombinant PR3 as solid-phase antigen

D. Roggenbuck, T. Büttner, L. Hoffmann, H. Schmechta, D. Reinhold, K. Conrad: High sensitive detection of autoantibodies to proteinase 3 (PR3) by a novel anchor ELISA

I. Knütter, T. Büttner, J. Scholka, D. Roggenbuck, U. Anderer: A novel immunofluorescence assay for the Differentiation of pANCA and ANA


6.4: Systemic Sclerosis

K. Hanke, C. S. Brückner,M. Becker,W. Meyer,W. Schlumberger, G. Riemekasten: Anti-CENP-A and anti-CENP-B antibodies show high concordance and similar clinical associations in patients with systemic sclerosis despite completely different underlying protein sequences

L. Maes, K. Op De Be´eck, K.Van den Bergh, P.Verschueren, R.Westhovens, D. Blockmans, M. Mahler, X. Bossuyt: Evaluation of the in-house developed dot blot method and ELISA for the detection of anti-PM/Scl100 autoantibodies in systemic autoimmune diseases

M. Mahler,M. Siegemund,W.Meyer,M. Petschinka, M. J. Fritzler: Anti-PM/Scl-antibodies in systemic sclerosis: Comparison between PM1-Alpha ELISA and a line assay with recombinant PM/Scl-75c and PM/Scl-100

S. Costa, M. Mondini, V. Caneparo, Italian FIRMA Group, S. Landolfo,M. Gariglio: Anti-IFI16 autoantibodies: a new marker in autoimmunity

A. Ceribelli, I. Cavazzana, P. Airo, A. Tincani, F. Franceschini, B. A. Pauley, E. K. L. Chan, M. Satoh: Anti-Th/To antibodies in Italian scleroderma patients: clinical and immunological correlations and comparison with patients with anti-centromere (ACA) antibodies


Chapter 7: Pathogenetic Aspects and Serological Diagnostics of Organ Specific Autoimmune Diseases

7.1: Autoimmune Neurological Diseases

H. J.Willison: Peripheral neuropathies and anti-glycolipid antibodies

R. L. Humbel, G. Foerster, I. Hila, M. Toussaint: Antiganglioside antibodies a very heterogeneous family of biomarkers

U.Wurster, K. Kollewe, B. Mohammadi, T. Sinzenich, S. Petri: Ganglioside antibodies in amyotrophic lateral sclerosis

I. Janatkova, K. Malickova, A. Potmesilova, B. Potuznikova, T. Fucikova: Co-Incidence of serum anti-ganglioside antibodies and microbial infection in patients with inflammatory peripheral neuropathy

S. Jarius, C. Probst, K. Borowski, D. Franciotta, B.Wildemann,W. Stöcker, K.-P.Wandinger: Detection of antibodies to aquaporin-4 by indirect immunofluorescence employing a standardized recombinant target antigen

P.W. Modderman, I. Ketelslegers, R. Q. Hintzen, D. Hamann: Antibodies against aquaporin-4 in neuromyelitis optica: cell-based assay vs. immunoprecipitation assay

K.-P.Wandinger, J. Dalmau, K. Borowski, C. Probst, K. Fechner,W. Stöcker: Recombinant immunofluorescence assay for the detection of anti-glutamate receptor (type NMDA) antibodies in the differential diagnosis of autoimmune encephalopathies

J. Fraussen, K. Vrolix, P. Martinez-Martinez, M. Losen, R. Hupperts, A. Van Diepen, R. Medaer, B. VanWijmeersch, E. Meulemans, M. H. De Baets, P. Stinissen, V. Somers: Immortalized B cell lines from multiple sclerosis patients produce antibodies that bind an oligodendrocyte precursor cell line

C. Govarts, K. Somers, R. Hupperts, P. Jongen, P. Stinissen and V. Somers: Analysis of autoantibody profiles in cerebrospinal fluid and serum of a relapsing-remitting MS patient with active disease using Serological Antigen Selection

J. Svarcová, L. Fialová, A. Bartos, L. Cechova, D. Dolezil, I.M. Malbohan: Anti-tau antibodies in patients with multiple sclerosis

L. Fialová, J. Svarcová, A. Bartos, I.M. Malbohan: Avidity of antibodies against tau protein in patients with multiple sclerosis


7.2: Gastrointestinal and Liver Diseases

D. Roggenbuck, G. Hausdorf, L. Martinez-Gamboa, D. Reinhold, T. Büttner, C. Büning, E. Feist, K. Conrad: The zymogen granule membrane glycoprotein GP2 is a major autoantigen of pancreatic antibodies – relevance in diagnostics and pathogenesis of Crohn’s disease

W. Stöcker, B. Teegen, C. Probst, K. Aulinger-Stöcker, D. Ludwig, M.O. Glocker, L. Komorowski: CUZD1 and GP2 are the exocrine pancreas autoantigens in Crohn’s disease

L. Komorowski, B. Teegen, C. Probst,W. Schlumberger,W. Stöcker: ELISA for the detection of autoantibodies against DNA-bound lactoferrin in ulcerative colitis

D. Bouzid, Y. Ben Haj Hmida, A. Amouri, N. Mahfouth, A. Kammoun, M. Ben Ayed, H. Makni, N. Tahri, H. Masmoudi: Antineutrophil cytoplasmic antibodies and HLA II in ulcerative colitis Tunisian patients

D. Villalta, E. Tonutti, C. Prause, S. Koletzko, M. Stern, M.W. Laass, H. H. Uhlig, H. J. Ellis, P. J. Ciclitira, T. Richter, C. Dähnrich,W. Schlumberger, T. Mothes: Diagnosis of IgA-deficient coeliac disease by assay of IgG antibodies against deamidated gliadin (GAF3X)

M. Miler, A. Tesija Kuna, O. Zaja Franulovic, N. Vrkic: Antibodies against deamidated gliadin as a novel serologic marker for celiac disease

T. Krieger, F. Haag: Deamidated gliadin antibodies facilitate diagnosis in celiac disease

X.Guo, R. Lerner, L. Sana,W. Kumfert and T. Prestigiacomo: Validation of Bio-Rad gastrointestinal assays for use on the Evolis™ and Evolis™ twin plus systems

G. Hausdorf, D. Roggenbuck, E. Feist, T. Büttner, K. Conrad, C. Berg, R. Klein: Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA – revival of a disease-activity marker in autoimmune hepatitis (AIH)

A. Neininger, J. Kaiser, J.Weyand, C. Berg, S. Buck, R. Klein, H. Haubruck, B. Liedvogel: Use of recombinant autoantigens in profiling of PBC associated antibodies


7.3: Various Autoimmune Diseases and Cancer

M. Cojocaru, I.M. Cojocaru, I. Silosi, S. Rogoz: Prevalence of ovarian antibodies in women with unexplained recurrent pregnancy loss

K. Zöphel, P. von Landerberg, D. Roggenbuck, G.Wunderlich, T. Grüning, J. Kotzerke, K. J. Lackner, B. Rees Smith: TSH receptor antibody (TRAb) assays using human monoclonal autoantibody M22 are more sensitive than bovine TSH based assays

V. Kocoski, N. Beyersdorf, A. Schlipp, V. Boivin, T. Kerkau, R. Jahns: β1-adrenoreceptor autoantibodies in a Lewis rat model of dilated cardiomyopathy

C. Dähnrich, A. Rosemann, C. Probst, L. Komorowski, W. Schlumberger, W. Stöcker, A. Recke, C. Rose, D. Zillikens, E. Schmidt: ELISA using ectodomains of desmoglein 1 and 3 expressed in HEK293 for sensitive and specific detection of pemphigus autoantibodies

D. Sánchez, A. Pekáriková, L. Palová-Jelínková, T. Mothes, H. Tlaskalová-Hogenová, L. Tucková: Fine specificity of serum IgA and IgG autoantibodies against Calreticulin in oncological patients

A. Pekáriková, D. Sánchez, L. Palová-Jelínková, M. Simsová, Z. Benes, I. Janatková, I. Hoffmanová, P. Drastich, T. Mothes, H. Tlaskalová-Hogenová, L. Tucková: Occurrence of autoantibodies to calreticulin in oncological patients and patients from risk groups


Chapter 8: Biological Therapy of Autoimmune Diseases

M. Aringer, J. S. Smolen: Biological therapy of rheumatic diseases

A. Kessel, A. Snir, E. Toubi: The role of B cells in immunoregulation

F. Hiepe, B. F. Hoyer, I. M. Mumtaz, T. Yoshida, A. Radbruch: Targeting of memory plasma cells as therapeutic option in autoimmune diseases

D. Cornec and P. Youinou: Has B-cell depletion any effects on circulating autoantibody?

A. Kromminga: Immune reactions induced by therapeutic proteins

P. van Schouwenburg, G.Wolbink, L. Aarden, D.Wouters: Measuring anti-adalimumab levels in the presence of adalimumab

V. Kocoski, N. Beyersdorf,M.Merkl, D. Schmidt, V. Boivin, T. Kerkau, R. Jahns: Peptide-based immunotherapy of dilated cardiomyopathy in a Lewis rat model




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